Magaldrate
Generic Details
Generic Name
Magaldrate
Other Names
- Riopan
Drug Class
- Antacid
Chemical Formula
MgAl(OH)5CO3
Molecular Weight
156.375 g/mol
Mechanism of Action
- Neutralizes stomach acid
- Forms a protective barrier over the ulcer or irritated area in the stomach lining
Indications
- Acid indigestion
- Heartburn
- Stomach ulcers
- Gastroesophageal reflux disease (GERD)
Common Dosage Forms
- Tablet
- Liquid suspension
Typical Dosage
- 400-800 mg orally before meals and at bedtime
Pediatric Dosage
- Consult pediatrician for appropriate dosing
Geriatric Dosage
- May necessitate lower doses due to decreased renal function
Side Effects
- Constipation
- Diarrhea
- Upset stomach
Contraindications
- Hypersensitivity to magaldrate
Pregnancy Category
- Category B - no evidence of risk in humans
Lactation Safety
- Limited data available, use with caution
Drug Interactions
- May reduce the absorption of other drugs due to its antacid properties
Overdose Symptoms
- Severe vomiting
- Muscle weakness
- Confusion
Antidote for Overdose
- Symptomatic treatment
Storage Conditions
- Store at room temperature away from moisture and heat
Pharmacokinetics
- Absorption: Not significantly absorbed systemically
- Distribution: Primarily localized to the gastrointestinal tract
- Metabolism: Not metabolized
- Excretion: Primarily excreted unchanged in the urine
Precautions
- Caution in patients with renal impairment
- Avoid long-term use
- Monitor for electrolyte imbalances
Warnings
- Do not exceed recommended dose
- Consult healthcare provider before use in children or elderly