Magaldrate + Simethicone
Generic Details
Generic Name
Magaldrate-Simethicone
Other Names
Drug Class
- Antacid
- Antiflatulent
Chemical Formula
Molecular Weight
Mechanism of Action
- Magaldrate: Acts as an antacid by neutralizing stomach acid
- Simethicone: Acts as an antifoaming agent to reduce gas
Indications
- Heartburn
- Acid indigestion
- Gas
- Bloating
Common Dosage Forms
- Chewable tablets
- Oral suspension
Typical Dosage
- Magaldrate 400-800 mg with Simethicone 20-40 mg orally four times a day
Pediatric Dosage
- Dosage based on weight and age, consult pediatrician
Geriatric Dosage
- Dosage adjustment may be needed, consult healthcare provider
Side Effects
- Constipation
- Diarrhea
- Nausea
- Vomiting
Contraindications
- Hypersensitivity to any component of the product
Pregnancy Category
- Category C - Animal reproduction studies have shown an adverse effect on the fetus, no adequate and well-controlled studies in humans
Lactation Safety
- Limited data available, use with caution and consult healthcare provider
Drug Interactions
- No significant drug interactions reported
Overdose Symptoms
- Excessive vomiting
- Severe diarrhea
- Electrolyte imbalance
Antidote for Overdose
- Supportive care and monitoring of electrolytes
Storage Conditions
- Store at room temperature away from moisture and heat
Pharmacokinetics
- Absorption: Magaldrate: Poorly absorbed from the GI tract, Simethicone: Not absorbed systemically
- Distribution: Not well characterized
- Metabolism: Magaldrate: Not metabolized, Simethicone: Not metabolized
- Excretion: Magaldrate: Renally, Simethicone: Feces
Precautions
- Monitor for signs of electrolyte imbalance
Warnings
- Do not exceed the recommended dosage
- Consult healthcare provider before use in special populations