Maprotiline Hydrochloride
Generic Details
Generic Name
Maprotiline Hydrochloride
Other Names
- Ludiomil
- Deprilept
Drug Class
- Tetracyclic antidepressant
Chemical Formula
C20H24N2Cl
Molecular Weight
318.87 g/mol
Mechanism of Action
- Blocks the reuptake of norepinephrine at the presynaptic neuronal membrane
Indications
- Treatment of depression
Common Dosage Forms
- Tablet
Typical Dosage
- 50-150 mg per day in divided doses
Pediatric Dosage
- Not established
Geriatric Dosage
- Initiate at lower end of dosing range
Side Effects
- Dry mouth
- Constipation
- Orthostatic hypotension
- Sedation
- Weight gain
Contraindications
- Hypersensitivity to maprotiline
- Acute recovery phase following myocardial infarction
- Angle-closure glaucoma
Pregnancy Category
- Category C - Risk cannot be ruled out
Lactation Safety
- Use with caution, excreted in breast milk
Drug Interactions
- MAOIs
- SSRIs
- SNRIs
- Cimetidine
Overdose Symptoms
- Cardiac toxicity
- Seizures
- Coma
Antidote for Overdose
- No specific antidote, provide supportive care
Storage Conditions
- Store at room temperature away from moisture and heat
Pharmacokinetics
- Absorption: Well absorbed from the gastrointestinal tract
- Distribution: Highly protein-bound
- Metabolism: Primarily hepatic via CYP2D6
- Excretion: Excreted in urine and feces
Precautions
- Caution in patients with cardiovascular disease
- Monitor for suicidal ideation
Warnings
- May increase suicidal thoughts in children, adolescents, and young adults
Others
- May take several weeks for full therapeutic effect