Mebendazole
Generic Details
Generic Name
Mebendazole
Other Names
- Vermox
- Emverm
- Telmin
Drug Class
- Anthelmintic
Chemical Formula
C16H13N3O3
Molecular Weight
295.29 g/mol
Mechanism of Action
- Inhibits microtubule synthesis in parasitic worms, leading to immobilization and death of the worm
Indications
- Treatment of various parasitic worm infections, including pinworm, roundworm, whipworm, and hookworm infections
Common Dosage Forms
- Tablets
- Chewable tablets
- Oral suspension
Typical Dosage
- 100 mg tablets; 1-2 tablets as a single dose for most infections,
Pediatric Dosage
- Dosing based on weight; typically 100 mg as a single dose for children
Geriatric Dosage
- Similar to adult dosing; adjustments may be needed based on renal function
Side Effects
- Nausea
- Vomiting
- Abdominal pain
- Diarrhea
- Dizziness
Contraindications
- Hypersensitivity to mebendazole
- Pregnancy (especially first trimester)
Pregnancy Category
- C - Risk cannot be ruled out
Lactation Safety
- Limited data, consult healthcare provider
Drug Interactions
- Cimetidine (may increase mebendazole levels)
Overdose Symptoms
- Severe abdominal pain
- Convulsions
- Hypoglycemia
Antidote for Overdose
- Symptomatic and supportive treatment; no specific antidote
Storage Conditions
- Store at room temperature away from moisture and heat
Pharmacokinetics
- Absorption: Well absorbed from the gastrointestinal tract
- Distribution: Widely distributed in the body, including the liver
- Metabolism: Extensively metabolized in the liver
- Excretion: Excreted in the urine and feces
Precautions
- Monitor liver function tests during prolonged therapy
Warnings
- Risk of liver toxicity with high doses or prolonged use
- Not recommended for pregnant women