Mebeverine Hydrochloride

Generic Name

Mebeverine Hydrochloride

Other Names

• Mebeverine HCl
• Duspatalin
• Colofac

Drug Class

• Antispasmodic

Chemical Formula

C25H35NO5.HCl

Molecular Weight

466.01 g/mol

Mechanism of Action

• Acts directly on the smooth muscle in the gut causing it to relax

Indications

• Irritable bowel syndrome (IBS)
• Functional gastrointestinal disorders

Common Dosage Forms

• Tablet
• Syrup
• Capsule

Typical Dosage

• 135 mg three times a day before meals

Pediatric Dosage

• Not recommended for children under 18 years

Geriatric Dosage

• Adjustment may be needed in elderly patients with renal impairment

Side Effects

• Nausea
• Abdominal pain
• Diarrhea
• Dizziness

Contraindications

• Hypersensitivity to mebeverine
• Severe liver or kidney function impairment

Pregnancy Category

• Category B - No evidence of risk in humans

Lactation Safety

• Limited data available, caution advised

Drug Interactions

• May interact with anticholinergic drugs, causing increased side effects

Overdose Symptoms

• Confusion
• Hallucinations
• Seizures

Antidote for Overdose

• No specific antidote, symptomatic treatment

Storage Conditions

• Store in a cool, dry place away from sunlight

Pharmacokinetics

• Absorption: Rapidly absorbed from the gut
• Distribution: Protein-bound, primarily distributed in the gastrointestinal tract
• Metabolism: Undergoes extensive first-pass metabolism in the liver
• Excretion: Excreted mainly through urine

Precautions

• Caution in patients with glaucoma
• Monitor for signs of liver function abnormalities

Warnings

• Avoid alcohol consumption while taking mebeverine
• Do not crush or chew extended-release formulations

Others

• May take a few weeks to show full benefits in IBS treatment