Meclizine + Pyridoxine
Generic Details
Generic Name
Meclizine-Pyridoxine
Other Names
- Meclizine-Pyridoxine Combination
Drug Class
- Antiemetic
- Antivertigo
Chemical Formula
Molecular Weight
Mechanism of Action
- Meclizine - Blocks histamine H1 receptors in the vomiting center and labyrinthine apparatus.
- Pyridoxine (Vitamin B6) - Facilitates the conversion of L-DOPA to dopamine.
Indications
- Motion sickness
- Vertigo associated with Meniere's disease
Common Dosage Forms
- Tablet
Typical Dosage
- One tablet orally once daily
Pediatric Dosage
- Consult pediatrician for appropriate dosage
Geriatric Dosage
- Dose adjustment may be necessary, consult healthcare provider
Side Effects
- Drowsiness
- Dry mouth
- Constipation
- Blurred vision
Contraindications
- Hypersensitivity to Meclizine or Pyridoxine
- Narrow-angle glaucoma
Pregnancy Category
- Category B - No evidence of risk in humans
Lactation Safety
- Use with caution, excretion in breast milk is unknown
Drug Interactions
- CNS depressants
- Alcohol
- Anticholinergic drugs
Overdose Symptoms
- Severe drowsiness
- Seizures
- Hallucinations
Antidote for Overdose
- Supportive care
Storage Conditions
- Store at room temperature away from moisture and heat
Pharmacokinetics
- Absorption: Well absorbed from the gastrointestinal tract
- Distribution: Highly bound to plasma proteins
- Metabolism: Metabolized in the liver
- Excretion: Mainly excreted in the urine
Precautions
- Caution in elderly patients
- Caution while driving or operating machinery
Warnings
- May cause drowsiness, avoid alcohol consumption
Others
- May be taken with or without food