Methyl Salicylate + Menthol

Generic Details

Generic Name

Methyl-salicylate-menthol

Other Names

  • Menthol-Methyl salicylate topical
  • Bengay
  • Icy Hot

Drug Class

  • Topical Analgesic

Chemical Formula

C10H18O2-C7H6O3

Molecular Weight

288.31 g/mol-152.15 g/mol

Mechanism of Action

  • Methyl Salicylate acts as a counterirritant, producing a cooling sensation that distracts from pain
  • Menthol activates cold receptors, leading to a cooling sensation and analgesic effect

Indications

  • Muscle pain
  • Joint pain
  • Arthritis
  • Back pain
  • Bruises
  • Strains
  • Sprains

Common Dosage Forms

  • Cream
  • Gel
  • Lotion
  • Patch

Typical Dosage

  • Apply a thin layer to the affected area 3 to 4 times daily and rub in gently

Pediatric Dosage

  • Consult healthcare provider for appropriate dosage in children

Geriatric Dosage

  • Use with caution and follow healthcare provider's recommendations for dosage adjustments

Side Effects

  • Skin irritation
  • Redness
  • Burning sensation
  • Allergic reactions

Contraindications

  • Hypersensitivity to salicylates or menthol
  • Broken or damaged skin
  • Children under 2 years old

Pregnancy Category

  • Consult healthcare provider before use during pregnancy

Lactation Safety

  • Minimal systemic absorption; considered safe when used topically

Drug Interactions

  • No significant drug interactions reported with topical use

Overdose Symptoms

  • Severe skin irritation
  • Nausea
  • Vomiting
  • Dizziness

Antidote for Overdose

  • Discontinue use and seek medical attention

Storage Conditions

  • Store at room temperature away from moisture and heat

Pharmacokinetics

  • Absorption: Limited systemic absorption through intact skin
  • Distribution: Not well documented due to limited systemic effects
  • Metabolism: Methyl salicylate undergoes hydrolysis to salicylic acid
  • Excretion: Primarily eliminated through urine as metabolites

Precautions

  • Avoid contact with eyes, mucous membranes, or open wounds
  • Do not use with heating pads or bandages
  • Discontinue use if irritation occurs

Warnings

  • For external use only
  • Do not apply to wounds or damaged skin
  • Consult healthcare provider before use if pregnant or breastfeeding

Others

  • Avoid inhaling the vapors or applying near the nose or mouth