Antihemophilic Factor [Factor VIII]

Generic Details

Generic Name

Antihemophilic Factor (Factor VIII)

Other Names

  • Factor VIII
  • AHF
  • Antihemophilic Factor A

Drug Class

  • Coagulation Factor

Chemical Formula

Not applicable (Biological molecule)

Molecular Weight

Approximately 280 kDa

Mechanism of Action

  • Antihemophilic Factor (Factor VIII) plays a crucial role in the blood clotting cascade by assisting in the conversion of Factor X to Factor Xa, ultimately leading to the formation of a stable blood clot.

Indications

  • Hemophilia A (Inherited factor VIII deficiency)

Common Dosage Forms

  • Lyophilized powder for reconstitution for intravenous injection

Typical Dosage

  • The dosage is individualized based on the patient’s weight, severity of bleeding, and factor VIII levels. Dosage is measured in international units (IU) per kilogram of body weight.

Pediatric Dosage

  • Similar to adult dosing but adjusted based on weight and age.

Geriatric Dosage

  • No specific geriatric dosage adjustments are recommended

Side Effects

  • Common side effects may include allergic reactions, development of inhibitors, and infusion site reactions.

Contraindications

  • Known hypersensitivity to Antihemophilic Factor (Factor VIII) or its components.

Pregnancy Category

  • Category C - Risk cannot be ruled out, benefits should outweigh risks.

Lactation Safety

  • Limited data available; exercise caution or consider alternative treatments.

Drug Interactions

  • No significant drug interactions reported

Overdose Symptoms

  • Excessive doses can lead to thrombotic events

Antidote for Overdose

  • Antithrombin III

Storage Conditions

  • Store in the refrigerator at 2°C to 8°C (36°F to 46°F). Do not freeze.

Pharmacokinetics

  • Absorption: Following intravenous administration, Antihemophilic Factor (Factor VIII) is rapidly absorbed into the bloodstream.
  • Distribution: Distributed mainly in the blood and taken up by endothelial cells.
  • Metabolism: Metabolized by the liver.
  • Excretion: Excreted via the reticuloendothelial system.

Precautions

  • Monitor for allergic reactions during infusion.

Warnings

  • Inhibitor development, thromboembolic events, and infusion site reactions may occur.

Others

  • Regular monitoring of factor VIII levels is essential to adjust the dosage and prevent bleeding episodes.