Mesna
Generic Details
Generic Name
Mesna
Other Names
- Sodium 2-mercaptoethane sulfonate
Drug Class
- Cytoprotective agent
- Uroprotective agent
Chemical Formula
C2H5NaO3S2
Molecular Weight
164.18 g/mol
Mechanism of Action
- Binds and detoxifies acrolein, a urotoxic metabolite of ifosfamide and cyclophosphamide
Indications
- Prophylaxis of ifosfamide or cyclophosphamide-induced hemorrhagic cystitis
- Prevention of urothelial toxicity associated with high-dose chemotherapy
Common Dosage Forms
- Oral tablets
- Injectable solution
Typical Dosage
- 400 mg/m2 3 times daily on days of ifosfamide or cyclophosphamide treatment
Pediatric Dosage
- Dose based on body surface area
Geriatric Dosage
- Adjust dose based on renal function
Side Effects
- Nausea
- Vomiting
- Diarrhea
- Hypersensitivity reactions
- Hematological toxicity
Contraindications
- Hypersensitivity to mesna or its components
Pregnancy Category
- C - Risk cannot be ruled out
Lactation Safety
- Limited data available; caution advised
Drug Interactions
- Ifosfamide
- Cyclophosphamide
Overdose Symptoms
- Nausea
- Vomiting
- Hypotension
Antidote for Overdose
- Supportive care
Storage Conditions
- Store at room temperature away from moisture and heat
Pharmacokinetics
- Absorption: Rapidly absorbed after oral administration
- Distribution: Widely distributed in the body
- Metabolism: Partially metabolized in the liver
- Excretion: Mainly excreted unchanged in the urine
Precautions
- Monitor renal function
- Hydration therapy is recommended during treatment
Warnings
- Ensure adequate hydration to prevent crystalluria
Others
- Mesna should be given in conjunction with ifosfamide or cyclophosphamide to provide maximum protection against urothelial toxicity.