Sitagliptin + Metformin Hydrochloride

Generic Name

Sitagliptin-Metformin Hydrochloride

Other Names

• Janumet

Drug Class

• Antidiabetic combination medication

Chemical Formula

C25H32F3N3O5

Molecular Weight

523.533 g/mol

Mechanism of Action

• Sitagliptin - DPP-4 inhibitor, Metformin - Biguanide

Indications

• Type 2 Diabetes Mellitus

Common Dosage Forms

• Tablet

Typical Dosage

• 50mg/500mg, 50mg/850mg, 50mg/1000mg - 1-2 tablets twice daily

Pediatric Dosage

• Safety and efficacy not established

Geriatric Dosage

• Dose adjustment may be required

Side Effects

• Hypoglycemia, gastrointestinal upset, headache, joint pain

Contraindications

• Renal impairment (eGFR <30 mL/min), metabolic acidosis, hypersensitivity

Pregnancy Category

• Category B

Lactation Safety

• Use with caution

Drug Interactions

• NSAIDs, ACE inhibitors, diuretics

Overdose Symptoms

• Hypoglycemia, lactic acidosis

Antidote for Overdose

• Glucose for hypoglycemia, supportive care for lactic acidosis

Storage Conditions

• Store at room temperature away from moisture and heat

Pharmacokinetics

• Absorption: Well absorbed
• Distribution: Protein-bound
• Metabolism: Metformin - minimal, Sitagliptin - primarily in the liver
• Excretion: Metformin - renal, Sitagliptin - renal and fecal

Precautions

• Monitor renal function, discontinue before iodinated contrast imaging

Warnings

• Lactic acidosis risk, pancreatitis risk

Others

• Take with meals to reduce gastrointestinal side effects