Metoprolol Tartrate
Generic Details
Generic Name
Metoprolol Tartrate
Other Names
- Lopressor
Drug Class
- Beta-blocker
Chemical Formula
C15H25NO3
Molecular Weight
267.36 g/mol
Mechanism of Action
- Selective β1-adrenergic receptor blocker
Indications
- Hypertension
- Angina
- Heart failure
- Myocardial infarction
- Atrial fibrillation
Common Dosage Forms
- Tablet
- Injection
Typical Dosage
- 25-100 mg twice daily
Pediatric Dosage
- Not established
Geriatric Dosage
- Adjust dosage based on renal function
Side Effects
- Fatigue
- Dizziness
- Bradycardia
- Hypotension
- Heart failure exacerbation
Contraindications
- Bradycardia
- Heart block greater than first degree
- Cardiogenic shock
- Severe hypotension
Pregnancy Category
- C
Lactation Safety
- Limited data available, caution advised
Drug Interactions
- Digoxin
- Verapamil
- Rifampin
- Epinephrine
Overdose Symptoms
- Bradycardia
- Hypotension
- Cardiac arrest
Antidote for Overdose
- Atropine
- Intravenous fluids
- Cardiac monitoring
Storage Conditions
- Store at room temperature away from moisture and heat
Pharmacokinetics
- Absorption: Rapidly and completely absorbed
- Distribution: Crosses the blood-brain barrier and placenta, excreted in breast milk
- Metabolism: Hepatic via CYP2D6
- Excretion: Mainly renal
Precautions
- Patients with diabetes
- Patients with asthma or COPD
- Thyrotoxicosis
Warnings
- Abruptly stopping may worsen angina or precipitate MI
- May mask signs of hypoglycemia in diabetics
Others
- Should be used with caution in patients with a history of bronchospasm