Metronidazole + Miconazole Nitrate

Generic Details

Generic Name

Metronidazole-Miconazole-Nitrate

Other Names

  • Metronidazole Miconazole Nitrate Combination

Drug Class

  • Antibacterial
  • Antifungal

Chemical Formula

C13H19N3O3•C18H14Cl4N2O•HNO3

Molecular Weight

660.82 g/mol (Metronidazole) + 479.92 g/mol (Miconazole Nitrate)

Mechanism of Action

  • Metronidazole: Bactericidal activity via DNA synthesis inhibition
  • Miconazole: Fungistatic activity via ergosterol synthesis inhibition

Indications

  • Vaginal infections caused by susceptible organisms

Common Dosage Forms

  • Vaginal cream
  • Vaginal suppositories

Typical Dosage

  • Apply intravaginally once daily for 7 days

Pediatric Dosage

  • Safety and efficacy not established in children

Geriatric Dosage

  • Dosage adjustments may be needed based on renal function

Side Effects

  • Vaginal burning
  • Itching
  • Irritation
  • Discharge
  • Headache

Contraindications

  • Hypersensitivity to any component

Pregnancy Category

  • Category B: Generally considered safe during pregnancy

Lactation Safety

  • Caution advised, consult healthcare provider

Drug Interactions

  • Avoid concurrent use with disulfiram and alcohol

Overdose Symptoms

  • Symptoms may include seizures, nausea, and vomiting

Antidote for Overdose

  • No specific antidote, manage symptoms supportively

Storage Conditions

  • Store at room temperature away from moisture and heat

Pharmacokinetics

  • Absorption: Well absorbed through mucous membranes
  • Distribution: Widely distributed in body tissues
  • Metabolism: Metabolized in the liver
  • Excretion: Excreted in urine and feces

Precautions

  • Avoid contact with eyes
  • Do not use tampons while using vaginal products

Warnings

  • For vaginal use only
  • Discontinue if rash or allergic reaction occurs

Others

  • This combination product provides dual action against both bacterial and fungal vaginal infections.