Lansoprazole + Amoxicillin + Clarithromycin
Generic Details
Generic Name
Lansoprazole-Amoxicillin-Clarithromycin
Other Names
- LAC Therapy
Drug Class
- Proton Pump Inhibitor
- Penicillin Antibiotic
- Macrolide Antibiotic
Chemical Formula
Molecular Weight
Mechanism of Action
- Lansoprazole: Proton pump inhibitor - reduces stomach acid production
- Amoxicillin: Bactericidal - inhibits bacterial cell wall synthesis
- Clarithromycin: Bacteriostatic - inhibits protein synthesis in bacteria
Indications
- H. pylori eradication in peptic ulcer disease
- Triple therapy for Helicobacter pylori infection
- Severe bacterial infections when indicated
Common Dosage Forms
- Capsules
- Tablets
Typical Dosage
- Lansoprazole 30 mg, Amoxicillin 1 g, Clarithromycin 500 mg, all twice daily for 10-14 days
Pediatric Dosage
- Dosing based on weight and indication, consult pediatrician
Geriatric Dosage
- Adjust doses as necessary based on renal function
Side Effects
- Nausea
- Diarrhea
- Abdominal pain
- Headache
- Taste disturbance
- Allergic reactions
Contraindications
- Hypersensitivity to any component
- Severe renal impairment
Pregnancy Category
- Amoxicillin - B
- Clarithromycin - C (Avoid in first trimester)
- Lansoprazole - B
Lactation Safety
- Amoxicillin - Generally considered safe
- Clarithromycin - Limited data, caution advised
- Lansoprazole - Limited data, caution advised
Drug Interactions
- Warfarin - Increase INR
- Theophylline - Increase levels
- Digoxin - Increase levels
Overdose Symptoms
- Nausea
- Vomiting
- Diarrhea
- Seizures
Antidote for Overdose
- Supportive care
Storage Conditions
- Store at room temperature (15-30°C)
- Protect from light and moisture
Pharmacokinetics
- Absorption:
- Distribution:
- Metabolism:
- Excretion:
Precautions
- Monitor for allergic reactions
- Assess renal function before treatment
- Avoid use in patients with history of gastrointestinal disease
Warnings
- Risk of antibiotic resistance with improper use
- Prolonged or repeated use may lead to fungal or bacterial superinfections