Milnacipran Hydrochloride
Generic Details
Generic Name
Milnacipran Hydrochloride
Other Names
- Savella
Drug Class
- Serotonin-Norepinephrine Reuptake Inhibitor (SNRI)
Chemical Formula
C15H22N2O
Molecular Weight
246.35 g/mol
Mechanism of Action
- Inhibits the reuptake of serotonin and norepinephrine
Indications
- Fibromyalgia
- Major Depressive Disorder
Common Dosage Forms
- Tablet
- Extended-release capsule
Typical Dosage
- 50 mg twice daily
Pediatric Dosage
- Not established
Geriatric Dosage
- Dose adjustments may be needed
Side Effects
- Nausea
- Headache
- Constipation
- Sweating
- Insomnia
Contraindications
- Hypersensitivity to milnacipran
- Uncontrolled narrow-angle glaucoma
Pregnancy Category
- Category C
Lactation Safety
- Not recommended during breastfeeding
Drug Interactions
- MAO inhibitors
- SSRIs
- SNRIs
Overdose Symptoms
- Seizures
- Cardiac arrhythmias
Antidote for Overdose
- No specific antidote, supportive care
Storage Conditions
- Store at room temperature away from light and moisture
Pharmacokinetics
- Absorption: Well absorbed orally
- Distribution: Distributed widely in the body
- Metabolism: Primarily hepatic
- Excretion: Mainly through urine
Precautions
- Caution in patients with a history of seizures
Warnings
- May increase suicidal thoughts in some patients
Others
- It may take several weeks to feel the full benefit of the medication