Montelukast Sodium
Generic Details
Generic Name
Montelukast Sodium
Other Names
- Singulair
Drug Class
- Leukotriene receptor antagonist
Chemical Formula
C35H34ClNNaO3S
Molecular Weight
608.18 g/mol
Mechanism of Action
- Blocks leukotriene receptors
Indications
- Asthma
- Allergic rhinitis
Common Dosage Forms
- Tablet
- Chewable tablet
- Oral granules
Typical Dosage
- 10 mg once daily in the evening for adults
Pediatric Dosage
- 2-5 years: 4 mg chewable tablet daily
- 6-14 years: 5 mg chewable tablet daily
Geriatric Dosage
- Dosage adjustment may be needed based on renal function
Side Effects
- Headache
- Fatigue
- Abdominal pain
- Dizziness
- Upper respiratory tract infection
Contraindications
- Hypersensitivity to Montelukast
- Acute asthma attacks
Pregnancy Category
- Category B
Lactation Safety
- Excreted in breast milk, caution is advised
Drug Interactions
- Phenobarbital
- Phenytoin
- Rifampin may decrease Montelukast levels
Overdose Symptoms
- Agitation
- Thirst
- Hyperactivity
Antidote for Overdose
- There is no specific antidote, symptomatic and supportive treatment is recommended
Storage Conditions
- Store at room temperature away from moisture and heat
Pharmacokinetics
- Absorption: Rapidly absorbed from the gastrointestinal tract
- Distribution: Highly protein-bound
- Metabolism: Undergoes extensive hepatic metabolism
- Excretion: Excreted mainly through bile
Precautions
- Patients with phenylketonuria should be cautious with chewable tablets containing aspartame
Warnings
- May cause neuropsychiatric events, including agitation, aggression, hallucinations
Others
- Montelukast is a prescription medicine and should not be used for acute asthma attacks