Rabeprazole + Amoxicillin + Clarithromycin

Generic Details

Generic Name

Rabeprazole-Amoxicillin-Clarithromycin

Other Names

  • RAC Regimen

Drug Class

  • Proton Pump Inhibitor (PPI)
  • Penicillin Antibiotic
  • Macrolide Antibiotic

Chemical Formula

Molecular Weight

Mechanism of Action

  • Rabeprazole: suppresses gastric acid secretion by inhibiting the proton pump
  • Amoxicillin: inhibits bacterial cell wall synthesis
  • Clarithromycin: inhibits bacterial protein synthesis

Indications

  • Helicobacter pylori eradication in peptic ulcer disease
  • Treatment of H. pylori infection in combination with other antibiotics

Common Dosage Forms

  • Capsules
  • Tablets

Typical Dosage

  • Rabeprazole 20 mg, Amoxicillin 1000 mg, Clarithromycin 500 mg, all twice daily for 7-14 days

Pediatric Dosage

  • Dosage varies based on weight and condition. Consult pediatrician.

Geriatric Dosage

  • May require dosage adjustment. Consult healthcare provider.

Side Effects

  • Nausea
  • Diarrhea
  • Abdominal pain
  • Headache
  • Taste perversion
  • Allergic reactions

Contraindications

  • Hypersensitivity to any component
  • Severe renal impairment
  • Severe hepatic impairment

Pregnancy Category

  • Rabeprazole: Category B
  • Amoxicillin: Category B
  • Clarithromycin: Category C

Lactation Safety

  • Limited data available, use with caution. Consider alternatives if possible.

Drug Interactions

  • Rabeprazole: interacts with drugs metabolized by CYP2C19
  • Amoxicillin: no significant drug interactions
  • Clarithromycin: interacts with many drugs, especially those metabolized by CYP3A4

Overdose Symptoms

  • Nausea
  • Vomiting
  • Diarrhea
  • Seizures

Antidote for Overdose

  • Supportive care, gastric lavage if necessary

Storage Conditions

  • Store at room temperature (20-25°C)
  • Protect from light and moisture

Pharmacokinetics

  • Absorption: Well absorbed
  • Distribution: Distributed widely in tissues
  • Metabolism: Partially metabolized in the liver
  • Excretion: Excreted mainly in urine and feces

Precautions

  • Monitor for allergic reactions
  • Assess renal and hepatic function before therapy
  • Educate patients on full course completion

Warnings

  • Potential for antibiotic resistance development
  • Prolonged use may lead to C. difficile infection

Others

  • Ensure patient compliance with dosing schedule and follow-up care.