Moxifloxacin Hydrochloride (Tablet)

Generic Details

Generic Name

Moxifloxacin Hydrochloride Tablet

Other Names

  • Moxifloxacin Tablet
  • Moxifloxacin HCl Tablet

Drug Class

  • Fluoroquinolone Antibiotic

Chemical Formula

C21H25ClFN3O4

Molecular Weight

437.89 g/mol

Mechanism of Action

  • Inhibition of DNA replication by targeting bacterial topoisomerases

Indications

  • Treatment of respiratory tract infections
  • Treatment of skin and skin structure infections
  • Treatment of urinary tract infections

Common Dosage Forms

  • 250 mg tablet
  • 400 mg tablet

Typical Dosage

  • 400 mg once daily for 7-14 days for respiratory tract infections
  • 400 mg once daily for 7 days for skin infections
  • 400 mg once daily for 10 days for urinary tract infections

Pediatric Dosage

  • Dosage adjustments required based on weight and age

Geriatric Dosage

  • No specific dosage adjustments required

Side Effects

  • Nausea
  • Diarrhea
  • Headache
  • Dizziness
  • Insomnia
  • Rash
  • Photosensitivity

Contraindications

  • Hypersensitivity to moxifloxacin or other fluoroquinolones
  • History of tendon disorders related to fluoroquinolone use

Pregnancy Category

  • C - Use with caution if benefits outweigh risks

Lactation Safety

  • Compatible with breastfeeding, monitor for diarrhea in infants

Drug Interactions

  • Avoid concurrent use with multivitamins/minerals or antacids containing zinc, magnesium, or aluminum
  • Increased risk of QT prolongation with class IA or class III antiarrhythmics

Overdose Symptoms

  • Seizures
  • Confusion
  • Vomiting
  • Tremors

Antidote for Overdose

  • No specific antidote, provide supportive care

Storage Conditions

  • Store at room temperature (20-25°C)
  • Protect from light and moisture

Pharmacokinetics

  • Absorption: Well absorbed after oral administration
  • Distribution: Extensively distributed in body tissues
  • Metabolism: Metabolized in the liver
  • Excretion: Excreted primarily in the urine

Precautions

  • Avoid in patients with known or suspected CNS disorders
  • Monitor for signs of tendinitis or tendon rupture

Warnings

  • May increase risk of tendinitis and tendon rupture
  • May cause exacerbation of myasthenia gravis symptoms

Others