Mupirocin
Generic Details
Generic Name
Mupirocin
Other Names
- Bactroban
Drug Class
- Topical Antibiotic
Chemical Formula
C26H44O9
Molecular Weight
500.63 g/mol
Mechanism of Action
- Inhibits bacterial protein synthesis by binding to isoleucyl-tRNA synthetase
Indications
- Treatment of impetigo
- Treatment of skin infections such as folliculitis, furunculosis, and ecthyma
- Eradication of nasal colonization of methicillin-resistant Staphylococcus aureus (MRSA) in healthcare workers
Common Dosage Forms
- Topical ointment
- Nasal ointment
Typical Dosage
- Apply a small amount to affected area 2-3 times daily
Pediatric Dosage
- As per physician's recommendation
Geriatric Dosage
- Normal adult dosage unless otherwise specified by a healthcare provider
Side Effects
- Burning
- Stinging
- Itching
- Rash
Contraindications
- Hypersensitivity to mupirocin or any of the excipients
Pregnancy Category
- Category B - No evidence of risk in humans
Lactation Safety
- Compatible with breastfeeding when used as directed
Drug Interactions
- No significant drug interactions reported
Overdose Symptoms
- Unlikely with topical use, consult a healthcare professional if large amounts are accidentally ingested
Antidote for Overdose
- No specific antidote, treatment is symptomatic
Storage Conditions
- Store at controlled room temperature (20-25°C)
Pharmacokinetics
- Absorption: Limited systemic absorption through intact skin
- Distribution: Local distribution in skin and nasal mucosa
- Metabolism: Minimally metabolized
- Excretion: Primarily eliminated unchanged in the feces
Precautions
- Avoid contact with eyes
- Not for use in deep-seated infections or on mucous membranes
Warnings
- For external use only
- Discontinue if irritation or sensitization occurs