Antazoline + Tetryzoline
Generic Details
Generic Name
Antazoline-Tetryzoline
Other Names
- Ocu-Hist
- Otrivine-Antistin
Drug Class
- Antihistamine
- Vasoconstrictor
Chemical Formula
C28H34N4
Molecular Weight
422.59 g/mol
Mechanism of Action
- Antazoline - Antihistamine
- Tetryzoline - Alpha-adrenergic agonist
Indications
- Allergic conjunctivitis
- Eye redness
- Eye irritation
Common Dosage Forms
- Ophthalmic solution
- Eye drops
Typical Dosage
- 1 to 2 drops instilled into the affected eye(s) every 4 to 6 hours
Pediatric Dosage
- Safety and efficacy not established in children under 6 years of age
Geriatric Dosage
- Dose reduction may be required in elderly patients
Side Effects
- Stinging or burning in the eye
- Blurred vision
- Headache
- Increase in blood pressure
Contraindications
- Hypersensitivity to antazoline or tetryzoline
- Narrow-angle glaucoma
- Severe cardiovascular disease
Pregnancy Category
- C - Consult healthcare provider before use
Lactation Safety
- Unknown if excreted in breast milk, consult healthcare provider before use
Drug Interactions
- Monoamine oxidase inhibitors (MAOIs)
- Tricyclic antidepressants
Overdose Symptoms
- Severe headache
- Increased blood pressure
- Tachycardia
Antidote for Overdose
- No specific antidote, symptomatic and supportive treatment
Storage Conditions
- Store at room temperature away from light and moisture
Pharmacokinetics
- Absorption: Well absorbed through the conjunctiva
- Distribution: Not well characterized
- Metabolism: Metabolized in the liver
- Excretion: Mainly excreted in the urine
Precautions
- Avoid contact lens wear during therapy
- Use with caution in patients with hypertension or hyperthyroidism
Warnings
- Prolonged use may lead to rebound hyperemia
- Discontinue use if irritation persists
Others
- Always wash hands before and after use, avoid touching the tip of the dropper to prevent contamination