Naproxen Sodium
Generic Details
Generic Name
Naproxen-Sodium
Other Names
- Anaprox
- Naprelan
- Naprosyn
- Aleve
Drug Class
- Nonsteroidal Anti-Inflammatory Drug (NSAID)
Chemical Formula
C14H13NaO3
Molecular Weight
252.24 g/mol
Mechanism of Action
- Inhibits the enzyme cyclooxygenase, leading to decreased prostaglandin synthesis
Indications
- Pain relief
- Fever reduction
- Inflammatory conditions such as arthritis
Common Dosage Forms
- Tablet
- Suspension
- Extended-release tablet
- Liquid-filled capsule
Typical Dosage
- 250-500 mg every 12 hours
Pediatric Dosage
- Not recommended for children under 2 years old
Geriatric Dosage
- Lower doses or longer dosing intervals may be required
Side Effects
- Stomach upset
- Ulcers
- Kidney problems
- High blood pressure
Contraindications
- Hypersensitivity to naproxen or other NSAIDs
- Active peptic ulcer disease
Pregnancy Category
- Category C - Risk cannot be ruled out
Lactation Safety
- Limited data available, caution advised
Drug Interactions
- Aspirin
- Anticoagulants
- Lithium
- Diuretics
Overdose Symptoms
- Nausea
- Vomiting
- Headache
- Dizziness
- Gastric bleeding
Antidote for Overdose
- Activated charcoal
- Supportive care
Storage Conditions
- Store at room temperature away from moisture and heat
Pharmacokinetics
- Absorption: Rapid and complete
- Distribution: Crosses the placenta, enters breast milk
- Metabolism: Mainly hepatic
- Excretion: Primarily renal
Precautions
- Avoid in patients with a history of asthma
- Use with caution in the elderly or patients with renal impairment
Warnings
- Increased risk of cardiovascular events
- May increase the risk of serious gastrointestinal adverse events
Others
- Avoid alcohol consumption while taking naproxen