Natamycin
Generic Details
Generic Name
Natamycin
Other Names
- Pimaricin
Drug Class
- Antifungal agent
Chemical Formula
C33H47NO13
Molecular Weight
665.74 g/mol
Mechanism of Action
- Natamycin disrupts fungal cell membrane function by binding to ergosterol, a key component in fungal cell membranes, leading to cell death.
Indications
- Treatment of fungal infections, particularly ocular infections such as fungal keratitis.
Common Dosage Forms
- Ophthalmic suspension
Typical Dosage
- 1-2 drops every 1-2 hours initially, then tapered based on clinical response.
Pediatric Dosage
- Dosing based on pediatric ophthalmologist's recommendation.
Geriatric Dosage
- Dosing based on ophthalmologist's recommendation considering renal and hepatic function.
Side Effects
- Eye irritation, blurred vision, eye redness, allergic reactions such as itching or rash.
Contraindications
- Hypersensitivity to natamycin or any components of the formulation.
Pregnancy Category
- Category C - Caution advised; benefits should outweigh risks.
Lactation Safety
- Use with caution; consult healthcare provider
Drug Interactions
- No significant drug interactions reported.
Overdose Symptoms
- Limited information available; contact poison control for assistance.
Antidote for Overdose
- No specific antidote; symptomatic and supportive measures recommended.
Storage Conditions
- Store at room temperature away from moisture and heat.
Pharmacokinetics
- Absorption: Minimal systemic absorption after ocular administration.
- Distribution: Limited distribution into systemic circulation.
- Metabolism: Not extensively metabolized.
- Excretion: Mainly excreted unchanged in feces.
Precautions
- Avoid contact with soft contact lenses; remove lenses before instilling drops.
Warnings
- Use as prescribed; prolonged use may lead to superinfection.
Others
- The efficacy of natamycin in the treatment of other types of fungal infections has not been well-established.