Nebivolol Hydrochloride
Generic Details
Generic Name
Nebivolol Hydrochloride
Other Names
- Nebicard
- Bystolic
Drug Class
- Beta-blocker
Chemical Formula
C22H25F2NO4
Molecular Weight
405.44 g/mol
Mechanism of Action
- Selective beta-1 adrenergic receptor blocker
Indications
- Hypertension
- Heart failure
Common Dosage Forms
- Tablet
Typical Dosage
- 5-10 mg once daily
Pediatric Dosage
- Safety and efficacy not established in children
Geriatric Dosage
- Start at lower end of dosing range due to decreased renal function
Side Effects
- Fatigue
- Dizziness
- Bradycardia
- Headache
- Nausea
Contraindications
- Severe bradycardia
- Heart block greater than first degree
- Cardiogenic shock
Pregnancy Category
- C - Use with caution
Lactation Safety
- Limited data available, use caution
Drug Interactions
- Avoid concomitant use with non-dihydropyridine calcium channel blockers
- May enhance hypoglycemic effects of insulin and oral antidiabetic agents
Overdose Symptoms
- Bradycardia
- Hypotension
- Acute cardiac insufficiency
Antidote for Overdose
- Atropine may be used for bradycardia
Storage Conditions
- Store at room temperature away from moisture and heat
Pharmacokinetics
- Absorption: Well absorbed from the gastrointestinal tract
- Distribution: Highly bound to plasma proteins
- Metabolism: Mainly hepatic via conjugation
- Excretion: Primarily renal
Precautions
- Caution in patients with hepatic impairment
- Avoid abrupt discontinuation
Warnings
- May cause exacerbation of angina if discontinued abruptly
Others
- Can be taken with or without food