Nepafenac
Generic Details
Generic Name
Nepafenac
Other Names
- Nevanac
Drug Class
- Nonsteroidal Anti-Inflammatory Drug (NSAID)
Chemical Formula
C15H14N2O2
Molecular Weight
254.28 g/mol
Mechanism of Action
- Inhibits the activity of cyclooxygenase, reducing prostaglandin synthesis
Indications
- Treatment of pain and inflammation associated with cataract surgery
- Treatment of swelling and pain after ocular surgery
Common Dosage Forms
- Ophthalmic suspension
- Ophthalmic solution
Typical Dosage
- Instill 1 drop into the affected eye(s) 3 times daily
Pediatric Dosage
- Use and dose should be determined by a healthcare provider
Geriatric Dosage
- Use with caution under the guidance of a healthcare provider
Side Effects
- Blurred vision
- Eye irritation
- Increased sensitivity to light
- Eye pain
- Headache
Contraindications
- Hypersensitivity to NSAIDs
- History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
Pregnancy Category
- C - Use with caution
Lactation Safety
- Unknown if excreted in human breast milk, use caution
Drug Interactions
- Avoid concomitant use with other NSAIDs
Overdose Symptoms
- May include nausea, vomiting, headache, dizziness, and abdominal pain
Antidote for Overdose
- Supportive care and symptomatic treatment
Storage Conditions
- Store at room temperature away from light and moisture
Pharmacokinetics
- Absorption: Highly absorbed after ocular administration
- Distribution: Enters systemic circulation, protein binding is about 99%
- Metabolism: Metabolized in the eye to amfenac by hydrolases
- Excretion: Primarily excreted in the urine
Precautions
- Use with caution in patients with a history of bleeding disorders
Warnings
- Not for injection or oral administration
Others
- May cause temporary blurred vision, avoid driving or using machinery until vision is clear