Nicorandil
Generic Details
Generic Name
Nicorandil
Other Names
- Ikorel
Drug Class
- Potassium channel activator
- Vasodilator
Chemical Formula
C8H9N3O4
Molecular Weight
211.18 g/mol
Mechanism of Action
- Opens ATP-sensitive potassium channels
- Direct vasodilation of arteries and veins
Indications
- Angina pectoris
- Prevention of angina attacks
Common Dosage Forms
- Tablet
- Oral suspension
Typical Dosage
- 10-20 mg orally twice daily
Pediatric Dosage
- Safety and efficacy not established in children
Geriatric Dosage
- Dose adjustment may be required based on renal function
Side Effects
- Headache
- Flushing
- Dizziness
- Hypotension
- Gastrointestinal disturbances
Contraindications
- Hypersensitivity to nicorandil
- Severe hypotension
- Cardiogenic shock
Pregnancy Category
- Not recommended
Lactation Safety
- Caution advised. Limited data available.
Drug Interactions
- Nitroglycerin
- Sildenafil
- Antihypertensives
Overdose Symptoms
- Severe hypotension
- Methemoglobinemia
Antidote for Overdose
- No specific antidote. Symptomatic treatment.
Storage Conditions
- Store at room temperature away from moisture and heat.
Pharmacokinetics
- Absorption: Rapidly absorbed from the gastrointestinal tract
- Distribution: Well-distributed in body tissues
- Metabolism: Partially metabolized by the liver
- Excretion: Excreted mainly in the urine
Precautions
- Use with caution in patients with renal impairment
- Avoid abrupt withdrawal
Warnings
- May cause drug-induced ulcers in the gastrointestinal tract
- May worsen myocardial oxygen balance in some patients