Nikethamide

Generic Details

Generic Name

Nikethamide

Other Names

  • Coramin
  • Glycophen

Drug Class

  • Respiratory stimulant

Chemical Formula

C10H14N2O2

Molecular Weight

190.23 g/mol

Mechanism of Action

  • Nikethamide stimulates the respiratory center in the brain, leading to an increase in ventilation and improved oxygenation.

Indications

  • Respiratory depression
  • Drug-induced central nervous system depression
  • Shock
  • Carbon monoxide poisoning

Common Dosage Forms

  • Tablet
  • Injection

Typical Dosage

  • 50-250 mg orally three times a day

Pediatric Dosage

  • Consult with a pediatrician for appropriate dosing

Geriatric Dosage

  • Lower doses may be necessary due to decreased metabolism and excretion

Side Effects

  • Nausea
  • Vomiting
  • Headache
  • Sweating
  • Hypotension

Contraindications

  • Hypersensitivity to nikethamide
  • Acute pulmonary edema

Pregnancy Category

  • C - Safety during pregnancy has not been established

Lactation Safety

  • It is unknown whether nikethamide passes into breast milk, so caution is advised

Drug Interactions

  • May potentiate the effects of other CNS depressants

Overdose Symptoms

  • Severe CNS stimulation leading to convulsions and respiratory depression

Antidote for Overdose

  • Supportive care and symptomatic treatment

Storage Conditions

  • Store at room temperature away from moisture and heat

Pharmacokinetics

  • Absorption: Rapidly absorbed from the gastrointestinal tract
  • Distribution: Widely distributed in the body
  • Metabolism: Metabolized in the liver
  • Excretion: Excreted in the urine

Precautions

  • Use with caution in patients with cardiovascular diseases
  • Monitor for signs of CNS depression

Warnings

  • Avoid abrupt discontinuation in patients on prolonged therapy

Others

  • Nikethamide should be administered under the supervision of a healthcare provider in a clinical setting for certain indications.