Norethisterone Acetate
Generic Details
Generic Name
Norethisterone Acetate
Other Names
- Norethindrone Acetate
- Norethindrone-17-acetate
Drug Class
- Progestin
- Contraceptive Hormone
Chemical Formula
C22H28O3
Molecular Weight
340.46 g/mol
Mechanism of Action
- Progestational
- Anti-ovulatory
Indications
- Irregular Menstrual Cycles
- Endometriosis
- Menstrual Disorders
- Contraception
Common Dosage Forms
- Oral tablets
Typical Dosage
- 5mg-10mg daily for 5-10 days for menstrual disorders
Pediatric Dosage
Not recommended for use in children
Geriatric Dosage
Dosage adjustments may be necessary in elderly patients
Side Effects
- Nausea
- Headache
- Breast Tenderness
- Irregular Bleeding
Contraindications
- Pregnancy
- Breastfeeding
- Undiagnosed Vaginal Bleeding
- Liver Disease
Pregnancy Category
X - Contraindicated in Pregnancy
Lactation Safety
May pass into breast milk, caution advised
Drug Interactions
- Rifampicin
- St. John's Wort
- Anticonvulsants
Overdose Symptoms
- Nausea
- Vomiting
- Fatigue
Antidote for Overdose
No specific antidote, treatment is symptomatic
Storage Conditions
Store at room temperature away from moisture and heat
Pharmacokinetics
- Absorption: Well-absorbed orally
- Distribution: Protein-bound, metabolized in the liver
- Metabolism: Hepatic metabolism
- Excretion: Mainly excreted in urine
Precautions
- History of Blood Clots
- Hypertension
- Diabetes
Warnings
- Increased Risk of Blood Clots
- Cardiovascular Risks
Others
- May also be used in hormone replacement therapy