Nystatin (Oral)

Generic Name

Nystatin Oral

Other Names

• Mycostatin

Drug Class

• Antifungal

Chemical Formula

C47H75NO17

Molecular Weight

926.1 g/mol

Mechanism of Action

• Nystatin binds to ergosterol in the fungal cell membrane, leading to cell membrane disruption and ultimately cell death.

Indications

• Treatment of oral candidiasis (thrush)

Common Dosage Forms

• Oral suspension
• Tablets

Typical Dosage

• 100,000 to 500,000 units four times a day

Pediatric Dosage

• Dosing based on weight and age

Geriatric Dosage

• May require dosage adjustment based on renal function

Side Effects

• Nausea
• Vomiting
• Diarrhea
• Stomach pain
• Skin rash

Contraindications

• Hypersensitivity to nystatin or any component of the formulation

Pregnancy Category

• Category C - Safety during pregnancy has not been established; benefits should outweigh risks

Lactation Safety

• Considered safe to use while breastfeeding

Drug Interactions

• No significant drug interactions reported

Overdose Symptoms

• Not well documented, but large doses may cause gastrointestinal disturbances

Antidote for Overdose

• No specific antidote, symptomatic and supportive treatment

Storage Conditions

• Store at room temperature away from moisture and heat

Pharmacokinetics

• Absorption: Poor oral absorption
• Distribution: Limited distribution into tissues
• Metabolism: Not extensively metabolized
• Excretion: Primarily excreted unchanged in feces

Precautions

• Monitor for signs of allergic reaction

Warnings

• Discontinue if signs of hypersensitivity develop

Others

• Avoid contact with eyes