Olmesartan Medoxomil

Generic Details

Generic Name

Olmesartan-medoxomil

Other Names

  • Olmesartan

Drug Class

  • Angiotensin II Receptor Blocker (ARB)

Chemical Formula

C29H30N6O6

Molecular Weight

558.585 g/mol

Mechanism of Action

  • Blocks the binding of angiotensin II to AT1 receptors, leading to vasodilation and reduced aldosterone secretion.

Indications

  • Hypertension
  • Heart Failure

Common Dosage Forms

  • Tablet

Typical Dosage

  • 20-40 mg once daily

Pediatric Dosage

  • Not established

Geriatric Dosage

  • Start with lower doses due to potential age-related decrease in renal function

Side Effects

  • Dizziness
  • Fatigue
  • Hyperkalemia
  • Hypotension
  • Diarrhea

Contraindications

  • History of angioedema related to previous ACE inhibitor or ARB therapy
  • Severe hepatic impairment

Pregnancy Category

  • Category D

Lactation Safety

  • Limited data available, not recommended during lactation

Drug Interactions

  • Avoid use with aliskiren in patients with diabetes
  • May increase lithium levels

Overdose Symptoms

  • Hypotension
  • Bradycardia

Antidote for Overdose

  • Supportive care and monitoring

Storage Conditions

  • Store at room temperature away from moisture and heat

Pharmacokinetics

  • Absorption: Rapidly absorbed from the gastrointestinal tract
  • Distribution: Extensively distributed in the body, primarily bound to plasma proteins
  • Metabolism: Hepatic metabolism to active metabolite
  • Excretion: Excreted mainly in the feces

Precautions

  • Monitor electrolytes regularly
  • Use caution in renal artery stenosis
  • Avoid in bilateral renal artery stenosis

Warnings

  • Black box warning: A combination of olmesartan with aliskiren is contraindicated in patients with diabetes