Olopatadine Hydrochloride

Generic Details

Generic Name

Olopatadine Hydrochloride

Other Names

  • olopatadine HCl

Drug Class

  • Antihistamine
  • Mast cell stabilizer

Chemical Formula

C21H23ClN2O3

Molecular Weight

388.87 g/mol

Mechanism of Action

  • Blocks histamine receptors
  • Inhibits release of allergic mediators from mast cells

Indications

  • Allergic conjunctivitis
  • Allergic rhinitis

Common Dosage Forms

  • Ophthalmic solution
  • Ophthalmic drops

Typical Dosage

  • 0.1% ophthalmic solution, instill 1-2 drops in each affected eye twice daily

Pediatric Dosage

  • Safety and effectiveness not established under 3 years of age

Geriatric Dosage

  • Adjust dosage based on individual patient response

Side Effects

  • Bitter taste
  • Headache
  • Blurred vision
  • Burning or stinging sensation in the eye

Contraindications

  • Hypersensitivity to olopatadine or any component of the formulation

Pregnancy Category

  • Category C - Safety in pregnancy has not been established

Lactation Safety

  • Caution advised, not recommended for use during breastfeeding

Drug Interactions

  • No significant drug interactions reported

Overdose Symptoms

  • Transient burning, stinging, conjunctival injection

Antidote for Overdose

  • No specific antidote, symptomatic and supportive treatment

Storage Conditions

  • Store at room temperature away from light and moisture

Pharmacokinetics

  • Absorption: Minimal systemic absorption after ocular administration
  • Distribution: Not well characterized
  • Metabolism: Hepatic metabolism
  • Excretion: Mainly through urine

Precautions

  • Avoid contact lens wear during medication use
  • Do not touch dropper tip to any surface to prevent contamination

Warnings

  • Discontinue use if signs of hypersensitivity occur
  • Do not use in children under 3 years of age

Others

  • This medication is for ophthalmic use only