Omeprazole

Generic Details

Generic Name

Omeprazole

Other Names

  • Prilosec
  • Losec

Drug Class

  • Proton Pump Inhibitor

Chemical Formula

C17H19N3O3S

Molecular Weight

345.42 g/mol

Mechanism of Action

  • Inhibits gastric acid secretion by irreversibly blocking the enzyme H+/K+ ATPase pump

Indications

  • Gastroesophageal reflux disease (GERD)
  • Peptic ulcer disease
  • Helicobacter pylori eradication
  • Zollinger-Ellison syndrome

Common Dosage Forms

  • Capsule
  • Tablet
  • Powder for Suspension

Typical Dosage

  • 20-40mg once daily

Pediatric Dosage

  • Dose varies based on weight and condition, consult pediatrician

Geriatric Dosage

  • No adjustment necessary; consider dose reduction in severe liver impairment

Side Effects

  • Headache
  • Abdominal pain
  • Nausea
  • Diarrhea
  • Dizziness

Contraindications

  • Hypersensitivity to omeprazole
  • Co-administration with rilpivirine-containing products

Pregnancy Category

  • Category C - Risk cannot be ruled out

Lactation Safety

  • Limited data available; consult healthcare provider

Drug Interactions

  • Warfarin
  • Clopidogrel
  • Digoxin

Overdose Symptoms

  • Confusion
  • Blurred vision
  • Sweating

Antidote for Overdose

  • No specific antidote; supportive care

Storage Conditions

  • Store at room temperature (15-30°C)

Pharmacokinetics

  • Absorption: Rapidly absorbed in the small intestine
  • Distribution: Protein binding is approximately 95%
  • Metabolism: Primarily hepatic via CYP2C19 and CYP3A4
  • Excretion: Renal and fecal excretion

Precautions

  • Monitor for signs of hypomagnesemia
  • Avoid long-term use without medical supervision

Warnings

  • Increased risk of Clostridium difficile-associated diarrhea

Others

  • May reduce the absorption of certain medications; separate administration if needed