Ornidazole

Generic Details

Generic Name

Ornidazole

Other Names

Tiberal
Dazolic
Ornizid

Drug Class

Antiprotozoal
Antibacterial

Chemical Formula

C7H10ClN3O3S

Molecular Weight

219.7 g/mol

Mechanism of Action

Ornidazole is a synthetic nitroimidazole derivative with antiprotozoal and antibacterial properties. It works by entering the microbial cell, where it interacts with DNA and causes damage, leading to cell death.

Indications

Anaerobic bacterial infections
Protozoal infections
Trichomoniasis
Amebiasis
Giardiasis

Common Dosage Forms

Tablet
Suspension

Typical Dosage

500 mg orally twice a day for 5-10 days

Pediatric Dosage

Dosage varies based on weight and age. Consult a pediatrician for appropriate dosing.

Geriatric Dosage

Dosage adjustment may be necessary based on renal function. Consult a healthcare provider for appropriate dosing in the elderly.

Side Effects

Nausea
Vomiting
Headache
Metallic taste in the mouth
Dizziness
Peripheral neuropathy

Contraindications

Hypersensitivity to nitroimidazole compounds
First-trimester pregnancy

Pregnancy Category

C - Risk cannot be ruled out

Lactation Safety

Limited data available. Consult a healthcare provider before use during lactation.

Drug Interactions

Avoid alcohol during treatment with ornidazole as it may cause a disulfiram-like reaction

Overdose Symptoms

Nausea
Vomiting
Seizures
Encephalopathy

Antidote for Overdose

Symptomatic and supportive treatment

Storage Conditions

Store at room temperature away from moisture and heat

Pharmacokinetics

Absorption: Well absorbed after oral administration
Distribution: Widely distributed in tissues and body fluids
Metabolism: Undergoes hepatic metabolism
Excretion: Primarily excreted in urine

Precautions

Caution in patients with hepatic impairment
Monitor for neurological side effects
Avoid use in the first trimester of pregnancy

Warnings

May cause dizziness, caution when driving or operating machinery

Others

Ornidazole is not recommended for use in children under 3 years of age.