Oseltamivir
Generic Details
Generic Name
Oseltamivir
Other Names
- Tamiflu
Drug Class
- Neuraminidase inhibitors
Chemical Formula
C16H28N2O4
Molecular Weight
312.404 g/mol
Mechanism of Action
- Inhibition of neuraminidase enzyme
Indications
- Treatment of influenza A and B viruses
Common Dosage Forms
- Capsules
- Suspension
Typical Dosage
- 75 mg twice daily for 5 days
Pediatric Dosage
- Dosage based on weight
Geriatric Dosage
- Dose adjustment may be necessary
Side Effects
- Nausea
- Vomiting
- Headache
- Insomnia
- Dizziness
Contraindications
- Hypersensitivity to oseltamivir
Pregnancy Category
- C
Lactation Safety
- L3 - Moderately safe
Drug Interactions
- No significant interactions
Overdose Symptoms
- Nausea
- Vomiting
- Neuropsychiatric effects
Antidote for Overdose
- Supportive care
Storage Conditions
- Store at room temperature
Pharmacokinetics
- Absorption: Well absorbed from the gastrointestinal tract
- Distribution: Widely distributed in the body
- Metabolism: Metabolized in the liver
- Excretion: Excreted mainly in the urine
Precautions
- Renal impairment
- Hepatic impairment
Warnings
- Risk of neuropsychiatric events in influenza patients
Others
- Highly effective when started within 48 hours of symptom onset