Aspartame

Generic Details

Generic Name

Aspartame

Other Names

  • NutraSweet
  • Equal

Drug Class

  • Non-nutritive sweetener
  • Artificial sweetener

Chemical Formula

C14H18N2O5

Molecular Weight

294.3 g/mol

Mechanism of Action

  • Aspartame is a dipeptide composed of aspartic acid and phenylalanine. It provides a sweet taste without contributing significant calories.

Indications

  • Aspartame is used as a sugar substitute in various low-calorie or sugar-free foods and beverages.

Common Dosage Forms

  • Powder
  • Tablet
  • Liquid

Typical Dosage

  • Varies based on the product and intended use. Follow package instructions or healthcare provider's recommendation.

Side Effects

  • Headache
  • Dizziness
  • Mood changes
  • Digestive issues (e.g., diarrhea, bloating)

Contraindications

  • Individuals with phenylketonuria (PKU) who cannot metabolize phenylalanine should avoid aspartame.

Pregnancy Category

  • C

Lactation Safety

  • Considered safe in moderate amounts during breastfeeding.

Drug Interactions

  • No significant drug interactions reported.

Overdose Symptoms

  • Rare due to low-caloric nature, but high intake may cause headaches or gastrointestinal disturbances.

Storage Conditions

  • Store in a cool, dry place away from direct sunlight and moisture.

Pharmacokinetics

  • Absorption: Rapidly absorbed in the gastrointestinal tract.
  • Distribution: Widely distributed in the body.
  • Metabolism: Metabolized into aspartic acid, phenylalanine, and methanol.
  • Excretion: Excreted primarily in the urine.

Precautions

  • Individuals with known sensitivity to aspartame should avoid its consumption.

Warnings

  • Excessive intake may lead to adverse effects; use in moderation.