Oxybuprocaine Hydrochloride
Generic Details
Generic Name
Oxybuprocaine Hydrochloride
Other Names
- Benoxinate Hydrochloride
- Novesine
- Novesin
- Proculin
Drug Class
- Topical Anesthetic
Chemical Formula
C17H28ClNO3
Molecular Weight
327.86 g/mol
Mechanism of Action
- Blocks voltage-gated sodium channels, inhibiting nerve conduction
Indications
- Ophthalmic procedures
- Eye examinations
- Removal of foreign bodies from the eye
Common Dosage Forms
- Ophthalmic solution
Typical Dosage
- Instill 1 to 2 drops into the conjunctival sac of the eye(s) as needed
Pediatric Dosage
- Dosing adjustments may be needed based on weight and age
Geriatric Dosage
- Lower doses may be required due to decreased metabolism
Side Effects
- Burning sensation
- Stinging
- Redness of the eye
- Temporary blurred vision
Contraindications
- Hypersensitivity to local anesthetics
Pregnancy Category
- C - Safety in pregnancy has not been established
Lactation Safety
- Use with caution as it is unknown if excreted in breast milk
Drug Interactions
- No significant drug interactions reported
Overdose Symptoms
- Systemic toxicity, central nervous system depression
Antidote for Overdose
- Supportive care and monitoring
Storage Conditions
- Store at room temperature away from light and moisture
Pharmacokinetics
- Absorption: Rapidly absorbed through the cornea
- Distribution: Limited distribution in the eye tissues
- Metabolism: Metabolized in the liver
- Excretion: Excreted in urine as metabolites
Precautions
- Avoid contact with soft contact lenses
- Do not use if solution is discolored or contains particles
Warnings
- Not for injection
- Do not use for prolonged periods without medical supervision
Others
- Ensure patient's corneal integrity before use
- Do not touch the dropper tip to avoid contamination