Oxyphenonium Bromide
Generic Details
Generic Name
Oxyphenonium-bromide
Other Names
- Daricon
- Darinex
- Darenex
- Dartul
- Driptane
Drug Class
- Anticholinergic
Chemical Formula
C19H26BrNO3
Molecular Weight
400.31 g/mol
Mechanism of Action
- Blocks acetylcholine receptors, resulting in decreased smooth muscle contractions
Indications
- Treatment of gastrointestinal disorders such as irritable bowel syndrome and peptic ulcer disease
- Adjunctive therapy in the management of bladder spasms and urinary incontinence
Common Dosage Forms
- Tablet
- Injection
- Oral solution
Typical Dosage
- 5-10 mg 3-4 times daily
Pediatric Dosage
- Dosage based on weight and age, consult pediatrician
Geriatric Dosage
- Lower initial dosage with cautious titration under medical supervision
Side Effects
- Dry mouth
- Blurred vision
- Urinary retention
- Constipation
- Confusion
Contraindications
- Glaucoma
- Obstructive uropathy
- Myasthenia gravis
- Hypersensitivity to anticholinergics
Pregnancy Category
- Category B - Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women
Lactation Safety
- Use caution if breastfeeding, excretion in breast milk unknown
Drug Interactions
- May interact with other anticholinergic medications, CNS depressants, and drugs that affect QT interval
Overdose Symptoms
- Severe dry mouth
- Blurred vision
- Confusion
- Hallucinations
- Cardiac arrhythmias
Antidote for Overdose
- No specific antidote, provide supportive care
Storage Conditions
- Store at room temperature away from moisture and heat
Pharmacokinetics
- Absorption: Well absorbed after oral administration
- Distribution: Crosses the blood-brain barrier and placenta, enters breast milk
- Metabolism: Metabolized in the liver
- Excretion: Eliminated primarily in urine
Precautions
- Use caution in patients with autonomic neuropathy or hepatic impairment
Warnings
- May cause drowsiness and blurred vision, avoid driving or operating machinery until effects are known
Others
- May exacerbate symptoms of hyperthyroidism