Oxytetracycline + Polymixin B Sulphate

Generic Details

Generic Name

Oxytetracycline-Polymixin B-Sulphate

Other Names

    Drug Class

    • Antibiotic

    Chemical Formula

    Molecular Weight

    Mechanism of Action

    • Oxytetracycline inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit, and Polymyxin B disrupts the bacterial cell membrane, leading to cell death.

    Indications

    • Bacterial infections of the eye, ear, skin, and respiratory tract.

    Common Dosage Forms

    • Ointment
    • Eye/Ear Drops

    Typical Dosage

    • Apply a small amount of ointment to the affected area 1 to 3 times daily
    • Instill 1 to 2 drops in the affected eye/ear every 4 to 6 hours.

    Pediatric Dosage

      Geriatric Dosage

        Side Effects

        • Local irritation
        • Burning sensation
        • Itching
        • Redness

        Contraindications

        • Hypersensitivity to tetracyclines or polymyxins

        Pregnancy Category

        • Not recommended during pregnancy

        Lactation Safety

        • Use with caution while breastfeeding

        Drug Interactions

        • May interact with certain antibiotics and antacids

        Overdose Symptoms

        • Severe skin irritation
        • Eye irritation
        • Respiratory distress

        Antidote for Overdose

        • Symptomatic and supportive treatment

        Storage Conditions

        • Store at room temperature away from moisture and heat.

        Pharmacokinetics

        • Absorption:
        • Distribution:
        • Metabolism:
        • Excretion:

        Precautions

        • Avoid contact with eyes
        • Not for systemic use

        Warnings

        • Discontinue use if irritation persists
        • Do not use for prolonged periods without medical advice

        Others

        • Always consult with a healthcare provider before using this medication.