Pancreatin

Generic Name

Pancreatin

Other Names

• Pancrelipase
• Pancreatic Enzymes

Drug Class

• Enzyme Supplement

Chemical Formula

Not applicable (combination of various enzymes)

Molecular Weight

Not applicable

Mechanism of Action

• Pancreatin contains lipase, protease, and amylase enzymes that help in the digestion of fats, proteins, and carbohydrates, respectively.

Indications

• Pancreatic insufficiency due to cystic fibrosis
• Chronic pancreatitis
• Pancreatectomy
• Other conditions affecting pancreatic function

Common Dosage Forms

• Capsules
• Tablets
• Powder for oral administration

Typical Dosage

• Individualized based on the patient's needs and severity of pancreatic insufficiency

Pediatric Dosage

• Doses adjusted based on weight and severity of condition

Geriatric Dosage

• No specific dosage adjustments needed

Side Effects

• Nausea
• Abdominal cramps
• Diarrhea
• Allergic reactions (rare)

Contraindications

• Hypersensitivity to pancreatic enzymes

Pregnancy Category

• C - Risk cannot be ruled out

Lactation Safety

• Compatible with breastfeeding

Drug Interactions

• Antacids
• Proton pump inhibitors
• H2 blockers

Overdose Symptoms

• High blood levels of uric acid
• High blood levels of purines

Antidote for Overdose

• No specific antidote; symptomatic treatment

Storage Conditions

• Store at room temperature away from moisture and heat

Pharmacokinetics

• Absorption: Absorption of the enzymes occurs in the small intestine
• Distribution: Not applicable
• Metabolism: Metabolized in the small intestine
• Excretion: Excreted in feces

Precautions

• Monitor for signs of allergic reactions
• Adjust dosage based on response
• Monitor for changes in stool pattern

Warnings

• Consult a healthcare provider before use in case of known allergies or gastrointestinal conditions

Others

• Pancreatin is a pancreatic enzyme replacement therapy used to improve digestion in individuals with insufficient pancreatic function.