Paracetamol + Caffeine
Generic Details
Generic Name
Paracetamol-Caffeine
Other Names
- Acetaminophen-Caffeine
- Tylenol-Caffeine
Drug Class
- Analgesic
- Antipyretic
- Central Nervous System Stimulant
Chemical Formula
C8H9NO2-C8H10N4O2
Molecular Weight
151.16 g/mol-194.19 g/mol
Mechanism of Action
- Paracetamol - Inhibition of prostaglandin synthesis in the central nervous system
- Caffeine - Adenosine receptor antagonist and phosphodiesterase inhibitor
Indications
- Pain relief
- Fever reduction
- Migraine headaches
- Tension headaches
- Menstrual cramps
Common Dosage Forms
- Tablets
- Capsules
- Suspension
Typical Dosage
- 500 mg-1000 mg of paracetamol with 65 mg-130 mg of caffeine every 4-6 hours as needed
Pediatric Dosage
- Dosage based on weight and age, consult pediatrician
Geriatric Dosage
- Dosage adjustments may be needed, consult healthcare provider
Side Effects
- Nausea
- Insomnia
- Nervousness
- Upset stomach
- Dizziness
Contraindications
- Hypersensitivity to paracetamol or caffeine
- Severe liver or kidney disease
- Uncontrolled high blood pressure
Pregnancy Category
- Category C - Consult healthcare provider
Lactation Safety
- Limited data available, use with caution
Drug Interactions
- Warfarin
- Lithium
- Alcohol
Overdose Symptoms
- Severe nausea
- Vomiting
- Hypertension
- Seizures
Antidote for Overdose
- N-Acetylcysteine for paracetamol overdose
Storage Conditions
- Store at room temperature away from moisture and heat
Pharmacokinetics
- Absorption: Rapid and complete
- Distribution: Widely distributed in the body
- Metabolism: Primarily in the liver
- Excretion: Mainly in the urine
Precautions
- Avoid alcohol consumption while taking this medication
- Monitor for signs of liver toxicity
Warnings
- Do not exceed the recommended dose
- Do not take with other products containing paracetamol
Others
- May cause caffeine dependence if used chronically