Paracetamol + Tramadol Hydrochloride
Generic Details
Generic Name
paracetamol-tramadol-hydrochloride
Other Names
- Paracetamol-Tramadol HCl
Drug Class
- Analgesic combination
Chemical Formula
Molecular Weight
Mechanism of Action
- Paracetamol: Inhibits prostaglandin synthesis in the central nervous system. Tramadol: Acts as a μ-opioid receptor agonist and inhibits norepinephrine and serotonin reuptake.
Indications
- Moderate to severe pain management
Common Dosage Forms
- Tablet
- Capsule
Typical Dosage
- 1-2 tablets every 4-6 hours as needed for pain relief
Pediatric Dosage
- Consult pediatrician for appropriate dosing
Geriatric Dosage
- Lower initial doses may be required due to decreased clearance
Side Effects
- Nausea
- Vomiting
- Dizziness
- Constipation
- Headache
Contraindications
- Hypersensitivity to paracetamol, tramadol, or related opioids
- Severe respiratory depression
- Acute or severe bronchial asthma
Pregnancy Category
- Category C - Risk cannot be ruled out
Lactation Safety
- Use with caution, tramadol is excreted in breast milk
Drug Interactions
- MAO inhibitors
- Serotonergic drugs
- Warfarin
- CNS depressants
Overdose Symptoms
- Respiratory depression
- Extreme drowsiness
- Miosis
Antidote for Overdose
- Naloxone for opioid toxicity
Storage Conditions
- Store at room temperature away from moisture and heat
Pharmacokinetics
- Absorption: Well absorbed from the gastrointestinal tract
- Distribution: Tramadol widely distributed throughout the body
- Metabolism: Tramadol undergoes hepatic metabolism via CYP2D6
- Excretion: Primarily excreted in urine as metabolites
Precautions
- History of drug abuse or dependence
- Renal or hepatic impairment
- Elderly patients
Warnings
- May cause respiratory depression, especially at high doses or in sensitive patients