Pazopanib Hydrochloride
Generic Details
Generic Name
Pazopanib Hydrochloride
Other Names
- Votrient
Drug Class
- Tyrosine Kinase Inhibitor
Chemical Formula
C21H23N7O2S
Molecular Weight
437.52 g/mol
Mechanism of Action
- Inhibition of Vascular Endothelial Growth Factor Receptor (VEGFR), Platelet-derived Growth Factor Receptor (PDGFR), c-KIT, and FGFR
Indications
- Renal cell carcinoma
- Soft tissue sarcoma
- Advanced ovarian cancer
Common Dosage Forms
- Tablet
Typical Dosage
- 800 mg orally once daily
Pediatric Dosage
Geriatric Dosage
Side Effects
- Hypertension
- Fatigue
- Diarrhea
- Nausea
- Vomiting
- Hair discoloration
- Loss of appetite
Contraindications
- Hypersensitivity to pazopanib or any component of the formulation
Pregnancy Category
- D
Lactation Safety
- Not recommended during breastfeeding
Drug Interactions
- Strong CYP3A4 inhibitors/inducers
- Warfarin
- Digoxin
Overdose Symptoms
- Hypotension
- Bradycardia
- Prolonged QT interval
Antidote for Overdose
- Supportive care
Storage Conditions
- Store at room temperature away from light and moisture
Pharmacokinetics
- Absorption: Rapidly absorbed
- Distribution: Highly distributed in tissues
- Metabolism: Hepatic via CYP3A4
- Excretion: Mainly feces
Precautions
- Monitor blood pressure regularly
- Hepatotoxicity
- Cardiac effects
Warnings
- Hepatotoxicity
- Hypertension
- Cardiotoxicity