Pefloxacin Mesylate Dihydrate
Generic Details
Generic Name
Pefloxacin Mesylate Dihydrate
Other Names
- Pefloxacin
Drug Class
- Quinolone Antibiotic
Chemical Formula
C17H20FN3O3S
Molecular Weight
359.43 g/mol
Mechanism of Action
- Inhibition of bacterial DNA gyrase and topoisomerase IV enzymes
Indications
- Urinary tract infections
- Respiratory tract infections
- Skin and soft tissue infections
- Bone and joint infections
Common Dosage Forms
- Tablet
- Injection
- Oral Suspension
Typical Dosage
- 400 mg orally every 12 hours
Pediatric Dosage
- The dosage for children should be determined based on body weight and severity of the infection
Geriatric Dosage
- Adjust dosage based on renal function due to potential decreased clearance in the elderly
Side Effects
- Nausea
- Vomiting
- Diarrhea
- Headache
- Dizziness
- Photosensitivity
Contraindications
- Hypersensitivity to fluoroquinolones
- History of tendon disorders related to quinolone use
Pregnancy Category
- Category C - Risk cannot be ruled out
Lactation Safety
- Limited data available, caution advised
Drug Interactions
- Avoid concomitant use with multivitamins or mineral supplements containing iron, magnesium, or zinc as they can reduce absorption of pefloxacin
Overdose Symptoms
- Nausea
- Vomiting
- Tremors
- Seizures
Antidote for Overdose
- Supportive care and symptomatic treatment
Storage Conditions
- Store at room temperature away from moisture and heat
Pharmacokinetics
- Absorption: Well absorbed after oral administration
- Distribution: Distributed widely in body tissues
- Metabolism: Metabolized in the liver to inactive metabolites
- Excretion: Excreted primarily in the urine
Precautions
- Use with caution in patients with history of seizures
- Monitor for signs of tendonitis and tendon rupture
Warnings
- Risk of serious adverse effects including tendon rupture and peripheral neuropathy
Others
- Avoid prolonged exposure to sunlight due to increased risk of phototoxicity