Perindopril Arginine
Generic Details
Generic Name
Perindopril-Arginine
Other Names
- Perindopril Arginine
Drug Class
- Angiotensin-Converting Enzyme (ACE) Inhibitor
Chemical Formula
C19H32N2O5
Molecular Weight
388.47 g/mol
Mechanism of Action
- Inhibits ACE, leading to vasodilation and reduced aldosterone secretion.
Indications
- Hypertension
- Heart Failure
- Coronary Artery Disease
Common Dosage Forms
- Tablet
Typical Dosage
- 4-8 mg once daily
Pediatric Dosage
- Safety and efficacy not established in pediatric patients
Geriatric Dosage
- Dose adjustment may be required based on renal function
Side Effects
- Cough
- Hypotension
- Hyperkalemia
- Dizziness
Contraindications
- History of angioedema related to previous ACE inhibitor therapy
- Pregnancy
Pregnancy Category
- Category D
Lactation Safety
- Limited data available, consult healthcare provider
Drug Interactions
- Potassium-sparing diuretics
- NSAIDs
- Lithium
Overdose Symptoms
- Hypotension
- Electrolyte disturbances
Antidote for Overdose
- Supportive care
Storage Conditions
- Store at room temperature away from moisture and heat
Pharmacokinetics
- Absorption: Rapidly absorbed
- Distribution: Protein binding: 20%-30%
- Metabolism: Hepatic to active metabolite perindoprilat
- Excretion: Primarily renal
Precautions
- Renal impairment
- Hyperkalemia
- Aortic stenosis
Warnings
- Risk of angioedema
- Monitor renal function