Phenoxymethyl Penicillin [Penicillin V]
Generic Details
Generic Name
Phenoxymethyl-penicillin-penicillin-V
Other Names
- Penicillin V
- Phenoxymethylpenicillin
Drug Class
- Penicillin Antibiotic
Chemical Formula
C16H18N2O5S
Molecular Weight
350.39 g/mol
Mechanism of Action
- Inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs)
Indications
- Streptococcal infections
- Otitis media
- Pharyngitis
- Impetigo
Common Dosage Forms
- Tablet
- Oral suspension
Typical Dosage
- 250-500 mg every 6 hours
Pediatric Dosage
- Dosing based on weight and severity of infection
Geriatric Dosage
- Lower doses may be required due to decreased renal function
Side Effects
- Nausea
- Vomiting
- Diarrhea
- Allergic reactions (rash, itching)
Contraindications
- History of severe allergic reactions to penicillins or cephalosporins
Pregnancy Category
- Safe to use during pregnancy
Lactation Safety
- Safe to use while breastfeeding
Drug Interactions
- Probenecid (may increase penicillin levels in the blood)
Overdose Symptoms
- Seizures
- Confusion
- Nausea
- Vomiting
Antidote for Overdose
- Supportive care and symptomatic treatment
Storage Conditions
- Store at room temperature away from moisture and heat
Pharmacokinetics
- Absorption: Well-absorbed orally
- Distribution: Distributed widely in body tissues and fluids
- Metabolism: Partially metabolized in the liver
- Excretion: Excreted mainly via urine
Precautions
- Use with caution in patients with renal impairment
Warnings
- Complete full course of treatment to prevent antibiotic resistance