Atenolol + Chlorthalidone
Generic Details
Generic Name
Atenolol-Chlorthalidone
Other Names
- Tenoretic
Drug Class
- Beta Blocker
- Thiazide Diuretic
Chemical Formula
Molecular Weight
Mechanism of Action
- Atenolol - Selective Beta-1 adrenergic receptor blocker
- Chlorthalidone - Inhibits reabsorption of sodium and water in the distal tubules
Indications
- Hypertension
- Management of high blood pressure
Common Dosage Forms
- Tablet
Typical Dosage
- One tablet daily
Pediatric Dosage
- Not established
Geriatric Dosage
- May require dosage adjustment
Side Effects
- Dizziness
- Fatigue
- Bradycardia
- Electrolyte disturbances
Contraindications
- Hypersensitivity to atenolol or chlorthalidone
- Severe bradycardia
- Cardiogenic shock
Pregnancy Category
- C for atenolol
- B for chlorthalidone
Lactation Safety
- Atenolol passes into breast milk, chlorthalidone excretion into breast milk is unknown
Drug Interactions
- Digoxin
- Lithium
- NSAIDs
Overdose Symptoms
- Hypotension
- Bradycardia
- Hyponatremia
Antidote for Overdose
- Supportive care and monitoring
Storage Conditions
- Store at room temperature away from moisture and heat
Pharmacokinetics
- Absorption: Well absorbed from the gastrointestinal tract
- Distribution: Atenolol - Distributed into breast milk, Chlorthalidone - Crosses the placenta
- Metabolism: Atenolol - Partially metabolized in the liver, Chlorthalidone - Metabolized in the liver
- Excretion: Renally excreted
Precautions
- Renal impairment
- Hepatic impairment
- Diabetes
Warnings
- Abrupt withdrawal can lead to rebound hypertension
Others
- May cause photosensitivity reactions