Pitavastatin Calcium
Generic Details
Generic Name
Pitavastatin-Calcium
Other Names
- Livalo
Drug Class
- HMG-CoA reductase inhibitor
- Statins
Chemical Formula
C50H46CaF2N2O8
Molecular Weight
880.04 g/mol
Mechanism of Action
- Inhibits HMG-CoA reductase enzyme to reduce cholesterol synthesis
Indications
- Hyperlipidemia
- Dyslipidemia
- Hypercholesterolemia
Common Dosage Forms
- Tablets
Typical Dosage
- 2-4 mg once daily
Pediatric Dosage
- Not established
Geriatric Dosage
- Adjust dose cautiously in elderly patients
Side Effects
- Muscle pain
- Weakness
- Rhabdomyolysis
- Headache
- Nausea
Contraindications
- Active liver disease
- Pregnancy
- Breastfeeding
Pregnancy Category
- Category X - contraindicated in pregnancy
Lactation Safety
- Not recommended during breastfeeding
Drug Interactions
- Cyclosporine
- Gemfibrozil
- Erythromycin
Overdose Symptoms
- Muscle pain
- Myopathy
- Liver dysfunction
Antidote for Overdose
- There is no specific antidote, treatment is supportive
Storage Conditions
- Store at room temperature (20-25°C)
- Protect from light and moisture
Pharmacokinetics
- Absorption: Rapidly absorbed
- Distribution: Highly bound to plasma proteins
- Metabolism: Metabolized by CYP2C9 and CYP2C8 enzymes
- Excretion: Primarily excreted in feces
Precautions
- Monitor liver function tests before and during therapy
- Consider dose reduction in hepatic impairment
Warnings
- Risk of myopathy and rhabdomyolysis
- Regular monitoring of liver function
Others
- It may be taken with or without food