Pivmecillinam
Generic Details
Generic Name
Pivmecillinam
Other Names
- Pivampicillin
Drug Class
- Antibiotic
- Penicillin
Chemical Formula
C16H17N3O6S
Molecular Weight
371.39 g/mol
Mechanism of Action
- Inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs)
Indications
- Urinary tract infections
- Respiratory tract infections
- Skin and soft tissue infections
Common Dosage Forms
- Tablet
- Capsule
Typical Dosage
- 200-400 mg every 6 hours
Pediatric Dosage
- Dosing based on weight and age, to be determined by a healthcare provider
Geriatric Dosage
- Lower doses may be required due to reduced renal function
Side Effects
- Nausea
- Vomiting
- Diarrhea
- Allergic reactions like rash or hives
Contraindications
- Hypersensitivity to penicillins or beta-lactam antibiotics
Pregnancy Category
- Safe for use in pregnancy
Lactation Safety
- Considered safe during lactation
Drug Interactions
- Probenecid may increase levels of pivmecillinam
Overdose Symptoms
- Severe nausea
- Vomiting
- Diarrhea
Antidote for Overdose
- Supportive care and monitoring
Storage Conditions
- Store at room temperature away from moisture and heat
Pharmacokinetics
- Absorption: Well-absorbed orally
- Distribution: Distributed widely in body tissues
- Metabolism: Partially metabolized in the liver
- Excretion: Primarily excreted unchanged in the urine
Precautions
- Use with caution in patients with renal impairment
Warnings
- Risk of allergic reactions in patients with penicillin allergy