Pizotifen
Generic Details
Generic Name
Pizotifen
Other Names
- Pizotyline
- Sandomigran
- Pizotifen Malate
Drug Class
- Antihistamine
- Antiserotonergic
Chemical Formula
C19H21NS
Molecular Weight
295.44 g/mol
Mechanism of Action
- Antagonist of serotonin and histamine receptors
Indications
- Prophylaxis of migraine headaches
- Prevention of cluster headaches
- Treatment of vasomotor rhinitis
Common Dosage Forms
- Tablet
- Oral Solution
Typical Dosage
- 0.5-1.5 mg daily, in divided doses
Pediatric Dosage
- Not established
Geriatric Dosage
- May require lower doses due to decreased metabolism
Side Effects
- Sedation
- Weight gain
- Dry mouth
- Constipation
- Increased appetite
Contraindications
- Hypersensitivity to pizotifen
- Severe liver impairment
Pregnancy Category
- Category B - No evidence of risk in humans
Lactation Safety
- Limited data, caution advised
Drug Interactions
- MAO Inhibitors
- Sedatives
- Alcohol
Overdose Symptoms
- Drowsiness
- Confusion
- Seizures
Antidote for Overdose
- Supportive care and symptomatic treatment
Storage Conditions
- Store at room temperature away from moisture and heat
Pharmacokinetics
- Absorption: Well absorbed orally
- Distribution: Widely distributed in the body
- Metabolism: Hepatic
- Excretion: Mainly renal
Precautions
- Caution in patients with urinary retention
- May impair ability to drive or operate machinery
Warnings
- May cause drowsiness, avoid alcohol and other CNS depressants
Others
- May take several weeks to see the full effects on migraine prevention