Polyethylene Glycol 3350 + Electrolytes

Generic Details

Generic Name

Polyethylene-Glycol-3350-Electrolytes

Other Names

  • PEG-3350
  • Polyethylene Glycol-Electrolyte Solution

Drug Class

  • Osmotic Laxative

Chemical Formula

Not Applicable (Combination Product)

Molecular Weight

Not Applicable (Combination Product)

Mechanism of Action

  • Works by retaining water in the stool, resulting in softer and easier bowel movements

Indications

  • Treatment of occasional constipation
  • Bowel cleansing preparation for colonoscopy in adults

Common Dosage Forms

  • Oral solution

Typical Dosage

  • 17 grams of powder (dissolved in 8 ounces of water) every 10 minutes until 3-4 liters have been consumed for colonoscopy preparation

Pediatric Dosage

  • Dosage should be adjusted based on weight and medical condition in children

Geriatric Dosage

  • Dosage adjustments may be necessary in elderly patients

Side Effects

  • Abdominal bloating
  • Nausea
  • Vomiting
  • Anal irritation
  • Dehydration

Contraindications

  • Gastrointestinal obstruction
  • Severe inflammatory conditions of the colon

Pregnancy Category

  • Category C - Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans

Lactation Safety

  • Unknown if excreted in breast milk, consult healthcare provider before use

Drug Interactions

  • May interact with other medications that affect electrolyte balance

Overdose Symptoms

  • Severe diarrhea
  • Electrolyte imbalances

Antidote for Overdose

  • Symptomatic treatment and electrolyte replacement if necessary

Storage Conditions

  • Store at room temperature away from moisture and heat

Pharmacokinetics

  • Absorption: Minimally absorbed from the gastrointestinal tract
  • Distribution: Distributed in the gut lumen
  • Metabolism: Not metabolized
  • Excretion: Excreted unchanged in the feces

Precautions

  • Use with caution in patients with renal impairment
  • Monitor electrolyte levels during use

Warnings

  • Avoid prolonged or excessive use as it may lead to electrolyte imbalances

Others

  • Always consult a healthcare provider before use
  • Do not use for longer than 7 days without medical advice