Acyclovir (Topical)
Generic Details
Generic Name
Acyclovir topical
Other Names
- Acyclovir cream
- Acyclovir ointment
Drug Class
- Antiviral
Chemical Formula
C8H11N5O3
Molecular Weight
225.21 g/mol
Mechanism of Action
- Inhibits viral DNA synthesis
Indications
- Herpes labialis (cold sores)
Common Dosage Forms
- Topical cream
- Topical ointment
Typical Dosage
- Apply a thin layer to the affected area 5 times a day for 4 days
Pediatric Dosage
- Consult pediatrician
Geriatric Dosage
- Adjust dosage based on renal function
Side Effects
- Burning sensation at the application site
- Skin dryness or redness
Contraindications
- Hypersensitivity to acyclovir or any component of the formulation
Pregnancy Category
- Category B
Lactation Safety
- Low risk, can be used cautiously
Drug Interactions
- No significant interactions reported
Overdose Symptoms
- Unlikely with topical application
Antidote for Overdose
- N/A
Storage Conditions
- Store at room temperature away from moisture and heat
Pharmacokinetics
- Absorption: Minimal systemic absorption
- Distribution: Limited data available
- Metabolism: Primarily renal excretion unchanged
- Excretion: Renal elimination of unchanged drug
Precautions
- Avoid contact with eyes
- Do not apply to mucous membranes
Warnings
- Not for internal use
- Consult healthcare provider for recurrent or severe symptoms