Polyethylene Glycol

Generic Details

Generic Name

Polyethylene Glycol

Other Names

  • PEG

Drug Class

  • Osmotic Laxative

Chemical Formula

HO-(CH2-CH2-O)n-H

Molecular Weight

Variable, depending on the polymer length

Mechanism of Action

  • Polyethylene glycol draws water into the colon, causing softening of stools and increased bowel movements

Indications

  • Constipation
  • Bowel preparation for colonoscopies

Common Dosage Forms

  • Oral powder for reconstitution
  • Oral solution
  • Capsules

Typical Dosage

  • 17 grams once daily
  • Or as directed by a healthcare provider

Pediatric Dosage

  • Dosage varies based on the child's age and weight

Geriatric Dosage

  • Dose adjustment may be needed based on renal function

Side Effects

  • Abdominal cramping
  • Diarrhea
  • Flatulence
  • Nausea

Contraindications

  • Known allergy to polyethylene glycol
  • Intestinal blockage
  • Severe inflammatory bowel disease

Pregnancy Category

  • Category C - Animal reproduction studies have shown an adverse effect on the fetus

Lactation Safety

  • Limited data available, caution advised

Drug Interactions

  • No significant drug interactions reported

Overdose Symptoms

  • Severe diarrhea
  • Electrolyte imbalances

Antidote for Overdose

  • Treatment is symptomatic and supportive

Storage Conditions

  • Store at room temperature away from moisture and heat

Pharmacokinetics

  • Absorption: Minimally absorbed orally
  • Distribution: Distributed in the colon
  • Metabolism: Not metabolized
  • Excretion: Excreted unchanged in feces

Precautions

  • Ensure an adequate intake of fluids while taking polyethylene glycol

Warnings

  • Do not take polyethylene glycol if you have symptoms of appendicitis or intestinal blockage

Others

  • Always consult a healthcare provider before using polyethylene glycol for bowel preparation